INTRODUCTION Trace levels of iodide are necessary for normal physical and mental development; however, excess iodide can lead to thyroid disorders. Common sources of iodide include iodized table salt and seafood, but other food products also contain iodide. Within the dairy industry, iodophors are used as disinfectants, which can also lead to increased iodide consumption by the public. 1 A concern over high iodide levels in the diet has led to a nutritional labe領 requirement for iodide/iodine. In this Application Note, ion chromatography coupled with pulsed amperometric detection is used to determine iodide in milk products. This method is specific, sensitive, and rapid. Iodide is separated on the IonPac® AS11 column, which contains a hydrophilic, anion-exchange resin that is well suited to the chromatography of the relatively hydrophobic iodide anion. Using a nitric acid eluent, the iodide ion elutes from the column in less than 5 minutes. Although iodide can be detected by direct current (dc) amperometry on a silver working electrode, a pulsed amperometric waveform is used in this Application Note to improve the reproducibility of iodide analysis. 2 Like dc amperometry, the detection limit of iodide using pulsed amperometric detection is in the low µg/L range. 賽默飛戴安ICS-2100離子色譜系統(tǒng)