Abstract A fully articulated dog skeleton excavated from a 16th-century Neutral Iroquoian site in Ontario, Canada displays a distinctive osteological condition known as hypertrophic osteopathy (HPO). Ancient DNA (aDNA) analysis of the dog has isolated Mycobacterium tuberculosis complex DNA, linking the secondary condition of HPO to tuberculosis (TB) and representing the oldest known case of TB yet to be discovered in the domestic dog. We emphasize that dogs 首ld be considered as potential reservoirs of TB into the Americas. 2003 Elsevier Ltd. All rights reserved. Keywords: Ancient DNA; Dogs; Hypertrophic osteopathy; Iroquoian; Palaeopathology; Tuberculosis SPEX6770 全自動冷凍研磨機 SPEX6870 全自動冷凍研磨機 SPEX6970EFM 冷凍研磨機