Even though Supercritical Fluid Chromatography (SFC) was first demonstrated by Klesper et al. in 1962, 6 7 years earlier than High-Performance Liquid Chromatography (HPLC), its history is unfortunate and it has never been a main stream of chromatography. Why?Partly because an automated liquid chromatograph (LC), namely, an amino acid analyzer by Spackman, Stein and Moore, had already been commercially available in the late 1950s and there were actual needs for LC, while therewere no such needs for SFC except for some exotic samples such as metalloporphyrins and metallic chelates at that time. Rapid development of HPLC occurred in the 1970s overshadowed the development of SFC taken place at the same time. However, there are remarkable research works done in the 1960s, the 1970s and the 1980s that realized the todays modern SFC, and this poster will review these works. JASCO SFC4000超臨界流體