DST系列植入式動(dòng)物體溫與心律記錄儀有Nano、Micro、Milli和Centi等不同型號(hào)，可分別用于小鼠、大鼠、雪貂、猴、羊、牛等不同大小動(dòng)物體溫及心率監(jiān)測(cè)，植入式記錄儀紀(jì)錄的數(shù)據(jù)可通過通訊盒（Communication Box）下載到計(jì)算機(jī)上，或者通過無線遙測(cè)傳輸數(shù)據(jù)，廣泛應(yīng)用于實(shí)驗(yàn)動(dòng)物監(jiān)測(cè)、動(dòng)物生理生態(tài)研究、藥理學(xué)研究、病理學(xué)研究、毒性實(shí)驗(yàn)、病毒學(xué)、疫苗學(xué)、免疫學(xué)研究實(shí)驗(yàn)、能量代謝測(cè)量監(jiān)測(cè)等。主要特點(diǎn)如下：

1）生物親和性，陶瓷材質(zhì)，該產(chǎn)品是無鉛的，長(zhǎng)期植入；

2）體積小，準(zhǔn)確性高，穩(wěn)定性好，適合病毒及疫苗研發(fā)的動(dòng)物實(shí)驗(yàn)；

3）按照動(dòng)物福利3Rs標(biāo)準(zhǔn)設(shè)計(jì)；

4）參考文獻(xiàn)比較多，應(yīng)用靈活；

應(yīng)用案例 1 美國(guó)亞利桑那大學(xué)科研人員利用DST nano-T溫度記錄儀監(jiān)測(cè)小鼠尾部皮膚溫度變化，并于2017年發(fā)表“Effect of Estrogen Status on Circadian Core and Tail Skin Temperature Rhythms in Female Mice”一文。

DST nano-T溫度記錄儀及支架

應(yīng)用案例2 日本昭和大學(xué)科研人員利用DST nano-T腹腔植入方法于2017年在Heliyon雜志發(fā)表“Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice”一文。

應(yīng)用案例3 荷蘭科學(xué)家利用DST Micro-T腹腔植入方法于2014年在Journal of Virology雜志發(fā)表“Correlation between Virus Replication and Antibody Responses in Macaques following Infection with Pandemic Influenza A Virus”一文，作者認(rèn)為此種體溫測(cè)定方法比較準(zhǔn)確，如下所示：

應(yīng)用案例4 荷蘭神經(jīng)科學(xué)研究所科學(xué)家利用DST nano-T動(dòng)物背部植入方法于2016年在Endocrinology雜志發(fā)表“ffects of Intracerebroventricular Administration of Neuropeptide Y on Metabolic Gene Expression and Energy Metabolism in Male Rats”一文，并認(rèn)為DST nano-T是比較靈敏的體溫記錄儀。需要說明的是，也可備選美國(guó)Sable Systems International公司生產(chǎn)的Promethion動(dòng)物行為與代謝監(jiān)測(cè)系統(tǒng)，更細(xì)微地研究食物、行為、代謝與體溫之間的相互關(guān)系。

Promethion動(dòng)物行為與代謝監(jiān)測(cè)系統(tǒng)（單個(gè)籠舍）

應(yīng)用案例5 荷蘭科學(xué)家于2017年在Journal of Virology 雜志發(fā)表“Infection of the Upper Respiratory Tract with Seasonal Influenza A(H3N2) Virus Induces Protective Immunity in Ferrets against Infection with A(H1N1)pdm09 Virus after Intranasal, but Not Intratracheal, Inoculation”一文，介紹了雪貂腹腔植入Micro-T微型溫度記錄儀，可以記錄間隔10分鐘的體溫?cái)?shù)據(jù)。另外，也可以在雪貂頸部植入DST系列溫度、心率記錄儀，如下圖所示：

雪貂麻醉狀態(tài)頸部皮下植入陶瓷式心率、溫度記錄儀

應(yīng)用案例 6 美國(guó)普林斯頓大學(xué)科研人員于2008年發(fā)表了“Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Red Foxes Fed Infected Bird Carcasses”一文，介紹了紅狐腹腔部植入DST溫度記錄儀，并間隔15分鐘記錄體溫?cái)?shù)據(jù)。

另外，還可以給海洋哺乳動(dòng)物、鳥類、魚類、兩棲類、大型哺乳動(dòng)物植入不同型號(hào)溫度、心率、深度(高度)、活動(dòng)度、壓力、傾斜度等多功能記錄儀。如下圖：

部分參考文獻(xiàn)

Burdick Sanchez NC et al,. Weaned pigs experimentally infected with Salmonella display sexually dimorphic innate immune responses without affecting pathogen colonization patterns. Translational Animal Science (2017).

Chaise LL, Paterson W, Laske TG, Gallon SL, McCafferty DJ, Théry M, Ancel A, Gilbert C. Implantation of subcutaneous heart rate data loggers in southern elephant seals (Mirounga leonina). Polar Biology (2017).

Cox F, Roos A, Hafkemeijer N, Baart M, Tolboom J, et al. Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge. PLoS ONE (2015).

Dawson A. Daily cycles in body temperature in a songbird change with photoperiod and are weakly circadian. Journal of Biological Rhythms (2017).

de Jonge J, Isakova-Sivak I, van Dijken H, Spijkers S, Mouthaan J, Smolonogina T, Roholl P and Rudenko L. H7N9 Live attenuated influenza vaccine is highly immunogenic, prevents virus replication and protects against severe bronchopneumonia in ferrets. Molecular Therapy accepted article preview online 22 January 2016.

Dudek M, Knutelska J, Bednarski M, Nowinski L, Zygmunt M, Mordyl B, Gluch-Lutwin M, Kazek G, Sapa J, Pytka K. A Comparison of Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.PLoS ONE (2015).

Dudek M, Knutelska J, Bednarski M, Nowinski L, Zygmunt M, Mordyl B, Gluch-Lutwin M, Zareba P, Kulig K, Sapa J. Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity. European Journal of Pharmacology (2016).

Pent G and Fike JH. Sheep performance, grazing behaviour, and body temperatures in silvopasture systems. 2016 AFGC Conference Proceedings.

Roques P, Ljungberg K, Kümmerer BM, Gosse L, Dereuddre-Bosquet N, Tchitchek N, Halleng?rd D, García-Arriaza J, Meinke A, Esteban M, Merits A, Le Grand R, Liljestr?m P. Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus. JCI Insight (2017).

Schulze LS-Ch, Borchardt S, Ouellet V, Heuwieser W. Effect of a phase I Coxiella burnetii inactivated vaccine on body temperature and milk yield in dairy cows. Journal of Dairy Science, (Jan) 99(1) 2016.

Trethowan P, Fuller A, Haw A, Hart T, Markham A, Loveridge A, Hetem R, du Preez B, Macdonald DW. Getting to the core: Internal body temperatures help reveal the ecological function and thermal implications of the lions‘ mane. Ecology and Evolution (2016).

Trethowan PD, Hart T, Loveridge AJ, Haw A, Fuller A, Macdonald DW. Improved homeothermy and hypothermia in African lions during gestation. Biology Letters (2016).

Zhang Z, Foppen E, Su Y, Bisschop PH, Kalsbeek A, Fliers E and Boelen A. Metabolic effects of chronic T3 administration in the hypothalamic paraventricular and ventromedial nucleus in male rats. Endocrinology (2016).