Abstract: We have evaluated the effects of microwave irradiation on the solid-phase synthesis of B-peptides. Sequences designed to adopt the 14-helix, especially those containing the structure promoting residue trans-2-aminocyclohexanecarboxylix acid (ACHC), suffer from poor synthetic efficiency under standard SPPS conditions. A comparision of microwave and conventional heating shows that both provide excellent synthetic results for shorter sequences; however, we identify a clear benefit from microwave irradiation for longer B-peptides. 應(yīng)用微波輻射合成14-Helical-Peptides 摘要： 我們已經(jīng)評(píng)估微波輻射對(duì)固相合成B-peptides的影響在標(biāo)準(zhǔn)SPPS條件下, 序列用作吸納14-螺旋(14-Helix)是存在非常低的合成效率，尤其是那些含有trans-2-aminocyclohexanecarboxylix acid (ACHC) 殘余物的結(jié)構(gòu)比較微波加熱和常規(guī)加熱表明，兩者都能為合成短序列多肽提供zhuo越的綜合成果;但是，我們確定微波輻射也能夠?yàn)楹铣奢^長(zhǎng)的乙肽(-Peptides) 提供zhuo越的綜合成果 有關(guān)詳情請(qǐng)瀏覽培安公司的網(wǎng)站www.pynnco.com,電子郵件：sales@pynnco.com, 電話：010-65528800 CEM LibertyBlue 自動(dòng)多肽合成儀