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The Structure-Function Relationship of PAMAM Dendrimers as Robust Oil Dispersants
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2018-08-31 10:11 419閱讀次數(shù)
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PAMAMdendrimershaverecentlybeeninvestigatedasefficientandbiocompatibleoil11dispersantsutilizingtheirencapsulationcapacity;however,theirhighcationicchargedensityhas12beenshowntobecytotoxic.Itisthereforeimperativetomitigatecationiccharge-induced13toxicityandunderstandtheeffectsofsuchchanges.Presentedhereisasynergisticexperimental14andcomputationalapproachtoexaminetheeffectsofvaryingterminalsurfacechargeonthe15capacityofdendrimerstodispersemodelliner,polycyclicaromatic,andhybridhydrocarbons.16Unchargeddendrimerscollapsebyformingintra-molecularhydrogenbonds,whichreducethe17hostingcapability.Ontheotherhand,changingthesurfacechargesfrompositivetonegative18greatlyshiftsthepKaoftertiaryaminesofthePAMAMdendrimerinterior.Asaresult,the19negativelychargeddendrimershaveasignificantpercentageoftertiaryaminesprotonated,20~30%.Thisunexpectedchangeininteriorprotonationstatecauseelectrostaticinteractionswith21theanionicterminalgroups,leadingtocontractionandamarkeddecreaseinhydrocarbon22hostingcapacity.Thepresentworkhighlightstherobustnatureofdendrimeroildispersionandalsoilluminatespotentiallyunintendedorunanticipatedeffects23ofvaryingdendrimersurface24chemistryontheirencapsulationorhostingefficacy,whichisimportantfortheirenvironmental,25industrial,andbiomedicalapplications.
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The Structure-Function Relationship of PAMAM Dendrimers as Robust Oil Dispersants
PAMAMdendrimershaverecentlybeeninvestigatedasefficientandbiocompatibleoil11dispersantsutilizingtheirencapsulationcapacity;however,theirhighcationicchargedensityhas12beenshowntobecytotoxic.Itisthereforeimperativetomitigatecationiccharge-induced13toxicityandunderstandtheeffectsofsuchchanges.Presentedhereisasynergisticexperimental14andcomputationalapproachtoexaminetheeffectsofvaryingterminalsurfacechargeonthe15capacityofdendrimerstodispersemodelliner,polycyclicaromatic,andhybridhydrocarbons.16Unchargeddendrimerscollapsebyformingintra-molecularhydrogenbonds,whichreducethe17hostingcapability.Ontheotherhand,changingthesurfacechargesfrompositivetonegative18greatlyshiftsthepKaoftertiaryaminesofthePAMAMdendrimerinterior.Asaresult,the19negativelychargeddendrimershaveasignificantpercentageoftertiaryaminesprotonated,20~30%.Thisunexpectedchangeininteriorprotonationstatecauseelectrostaticinteractionswith21theanionicterminalgroups,leadingtocontractionandamarkeddecreaseinhydrocarbon22hostingcapacity.Thepresentworkhighlightstherobustnatureofdendrimeroildispersionandalsoilluminatespotentiallyunintendedorunanticipatedeffects23ofvaryingdendrimersurface24chemistryontheirencapsulationorhostingefficacy,whichisimportantfortheirenvironmental,25industrial,andbiomedicalapplications.[詳細(xì)]
2018-08-31 10:11
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