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A novel biodegradable amphiphilic diblock copolymers based on poly(lactic acid) and hyaluronic acid
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2018-08-31 10:11 760閱讀次數(shù)
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Anovelbiodegradableamphiphilicdiblockcopolymersbasedonpoly(lacticacid)andhyaluronicacidasbiomaterialsfordrugdelivery-Springer
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A novel biodegradable amphiphilic diblock copolymers based on poly(lactic acid) and hyaluronic acid
- Anovelbiodegradableamphiphilicdiblockcopolymersbasedonpoly(lacticacid)andhyaluronicacidasbiomaterialsfordrugdelivery-Springer[詳細(xì)]
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2018-08-31 10:11
產(chǎn)品樣冊
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Synthesis and Micellar Characterization of Amphiphilic Diblock Copolymers Based on Poly(2-ethyl-2-ox
- Amphiphilicdiblockcopolymersweresynthesizedbasedonpoly(2-ethyl-2-oxazoline)(PEtOz)asahydrophilicblockandaliphaticpolyesterssuchaspoly(L-lactide)(PLA)orpoly(-caprolactone)(PCL)asahydrophobicblock.Theirmicellarcharacteristicsinanaqueousphasewereinvestigatedbyusingdynamiclightscatteringandfluorescencetechniques.Theblockcopolymersformedmicellesintheaqueousphasewithcriticalmicelleconcentrations(cmcs)intherangeof1.0-8.1mg/L.Thecmcvaluesbecomeloweruponincreasingthelengthofthehydrophobicblock.Themeandiametersofthemicelleswereintherangeof108-192nm,withanarrowdistribution.Ingeneral,themicellesizeincreasedasthehydrophobicPLAorPCLblockbecamelarger.Thepartitionequilibriumconstants,Kv,ofpyreneinthemicellarsolutionsoftheblockcopolymerswerefrom1.79105to5.88105.ForeachblockcopolymersystemofPEtOz-PLAorPEtOz-PCL,theKvvalueincreasedasthelengthofthehydrophobicblockincreased.Thesteady-statefluorescenceanisotropyvalues(r)of1,6-diphenyl-1,3,5-hexatriene(DPH)were0.265-0.284inPEtOz-PLAsolutionand0.189-0.196inPEtOz-PCLsolution.TheanisotropyvaluesofPEtOz-PLAswerehigherthanthoseofPEtOz-PCLs.Theanisotropyvalueswereindependentofthelengthofthehydrophobicblockwhenthechemicalstructuresofthehydrophobicblockswereidentical.ThemicellesunderwenthydrogenbondingatpH<3.5withpoly(acrylicacid),whichproducedpolymercomplexprecipitatesthatcouldbereversiblydispersedasmicellesatpH>3.8.[詳細(xì)]
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2018-08-31 10:11
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TOWARD AMPHIPHILIC DIBLOCK COPOLYMERS BY RAFT. KINETIC STUDY ON PH RESPONSIVE POLYMERS
- Reversibleadditionfragmentationtransfer(RAFT)belongstothegroupofthecontrolledradicalpolymerization(CPR)methods,intensivelyemployedinthesynthesisofpolymerswithcomplexarchitecturesandstructures.1,2pHresponsiveamphiphiliccopolymerssynthesizedbyRAFT,leadtomaterialswithversatileproperties.OptimizationofthereactionkineticsduringRAFTpolymerizationof2-(dimethylamino)ethylacrylate(DMAEA)inN,Ndimethylformamide(DMF)wasinvestigatedinthisstudy,followedbythesynthesisofDMAEA/styreneamphiphilicdiblockcopolymers,usingAutomaticContinuousOnlineMonitoringofPolymerizationreactions(ACOMP).Poly(DMAEA)isapHsensitivepolymerwithwideapplicationsinpharmaceuticalandwatertreatmentindustriesyetchallengingduetopossibleinteractionofitsaminogroupwithcatalysts.[詳細(xì)]
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Influence of Cross-Linkers on the in Vitro Chondrogenesis of Mesenchymal Stem Cells in Hyaluronic Acid Hydrogels
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